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M. V. Nagabhushanam ¹, Ch. V . Prasada Rao ², M. Beena Devi ³, J. Suresh Kumar ⁴

Affiliations
1 DCRM Pharmacy College, Inkollu - 523 167, Prakasam (Dt.,) A.P., IN
2 Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar - 522510, Guntur, A.P., IN
3 Rahul Institute of Pharmaceutical Sciences & Research , Chirala - 523155, Prakasam Dt., A.P., IN
4 Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda Road, Yellamanda Post, Narasaraopet - 522601, Guntur Dt., A.P., IN

Abstract

The poor solubility and wettability of a non steroidal anti inflammatory drug, celecoxib leads to poor dissolution and hence, low bioavailability after oral administration. The objective of the present study was to formulate solid dispersions of celecoxib, with water soluble polymers poly vinyl pyrrolidine (PVP K30), poly ethylene glycol (PEG 6000), hydroxypropyl methylcellulose 5cps (HPMC) and a super disintegrant namely pregelatinised starch (PGS) by common solvent and solvent evaporation methods. Solid Dispersions prepared were evaluated for dissolution rate and dissolution efficiency in comparison to the corresponding pure drug. Solid dispersions of celecoxib showed a marked enhancement in dissolution rate and dissolution efficiency. The increasing order of dissolution rate of solid dispersions of celecoxib with various polymers was HPMC > PVP > PEG. Solid dispersions at 2:2:6 ratio of C: HPMC: PGS, a 53.57 fold increase in the dissolution rate of celecoxib was observed. Solid dispersions were characterized by infrared spectroscopy (IR), differential scanning calorimetry (DSC) and X-ray diffractogram (XRD). Solid dispersions in combined carriers gave much higher rates of dissolution than super disintegrant PGS alone. Super disintegrant PGS alone or in combination with hydrophilic polymers could be used to enhance the dissolution rate of poorly soluble drug celecoxib. Finally, in-vitro dissolution studies showed that celecoxib release was greatly improved by formation of solid dispersion.

Keywords

Celecoxib, Solid Dispersions, Dissolution Rate, Solubility, Superdisintegrant.

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M. Krishnaveni ¹, J. Suresh Kumar ¹, P. S. Sharvanan ²

Affiliations
1 Department of Botany, Government Arts College, TIRUVANNAMALAI (T.N.), IN
2 Department of Botany, Annamalai University, Annamalai Nagar, CHIDHAMBARAM (T.N.), IN

Abstract

Among heavy metals, lead is an element that is easily accumulated in soil and sediments. The level of lead found in plants is often correlated with the level present in the environment. Cowpea [Vigna unguiculata (L.) Walp.], a member of Fabaceae, it is an annual multi-purpose grain legume plants suitable in a variety of cropping systems. The present study on ecophysiological effect of lead is undertaken to analyse the influence of ead on biochemicals and proline contents of cowpea [Vigna unguiculata (L.) Walp.]. In this study, Co ^-1 was considered to be more tolerant than other varieties tested. The lead treatment up to 10mg kg ^-1 soil concentration was, however, beneficial for the overall growth parameters. From those treatments under lead values were increased at 10mg kg^-1 lead treatment. The uptake and accumulation of lead in cowpea plants increased with increased of lead level in the soil under field / pot culture experiments. From 25-200mg kg^-1 biochemical contents were decreased (except proline).

Keywords

Influence, Biochemicals, Proline, Vigna unguiculata.

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D. Venkata Ramana ¹, K. Narayana Rao ², J. Suresh Kumar ³

Affiliations
1 Mechanical Engineering Section, Govt. Polytechnic, Yadagirigutta, Telangana, IN
2 Mechanical Engineering Section, Department of Technical Education, Hyderabad, Andhra Pradesh, IN
3 Department of Mechanical Engineering, J.N.T.U., Hyderabad, Telangana, IN

Abstract

In recent years, performance measurement and metrics of organizations have received much attention from researchers and practitioners. The role of these measures and metrics in the success of an organization cannot be overstated because they affect strategic, tactical and operational planning and control. Performance measurement and metrics have an important role to play in setting objectives, evaluating performance and determining future courses of actions. Performance measurement and metrics pertaining to leagile supply chains have not received adequate attention from researchers or practitioners. In the area of supply chain management, application of MCDM methods is limited to supplier selection and transportation carrier selection.

In this paper, fifteen organizations involved in production of apparels in Telangana and Andhra Pradesh are considered for evaluation of supply chain strategies in leagile perspective using DEMATEL-AHP methodology. AHP frame work is developed with level 0 as goal of analyzing the leagile performance of the supply chains. Performance measures are considered in level 1. Level 2 contains enablers of the performance measures of leagile supply chains. Level 3 contains fifteen supply chain organizations. Weights of the performance enablers are determined through FPIR and FNIR approach without interdependence. DEMATEL is employed to determine the relative weights of the performance enablers from interdependence. DEMATEL is employed to determine the relative weights of the performance enablers from interdependence. Global weights of performance enablers are determined by successively multiplying the weights of performance measures with the weights respective enablers. Evaluation of supply chains in leagile perspective is done by finding out leagile index obtained by weighted sum of payoff of the enablers.

Keywords

Leagile Supply Chain Strategy, Leagile Index, Performance Measurement, Performance Enablers, Flexibility.

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Nadendla Srinivasababu ¹, J. Suresh Kumar ², K. Vijaya Kumar Reddy ²

Affiliations
1 Department of Mechanical Engineering, Vignan’s Lara Institute of Technology and Science, Vadlamudi -522213, Andhra Pradesh, IN
2 Department of Mechanical Engineering, INTUH College of Engineering, Hyderabad - 85, Andhra Pradesh, IN

Abstract

The healthy environment for leading happy life of biotic community invited the development of green materials. In the present work, a new natural fibre i.e. Palm Fruit Empty Fruit Bunch (EFB) is extracted by Hot Water Immersion (HWI) method, and is characterized for its tensile and morphological properties. Palm fruit EFB fibre chemical treatment - 1 (CT - 1) reinforced polyester composites exhibit tensile strength of 27.62 MPa at 7.62% fibre volume fraction whereas untreated fibre reinforced composites show 758.23 MPa tensile modulus at 13.28 % fibre volume fraction. The maximum flexural strength (47.54 MPa), modulus (2.51 GPa) are achieved with the reinforcement of chemically treated fibre in polyester matrix at maximum fibre volume fraction (20.68 %). Increasing trend of impact strength is visualized with the increase in fibre content, and maximum value of 6.45 kJ/m2 is obtained at 24.05 % fibre volume fraction. The dielectric strength of 6 kV/mm is seen at 17.7% fibre volume fraction.

Keywords

Palm Fruit EFB, Hot Water Immersion, Mechanical Properties, Dielectric Strength, Scanning Electron Micrograph.

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